Welcome to the laboratory of Dr. Brad Day at Michigan State University!

Research in our lab focuses on the molecular-genetic and biochemical investigation of plant-pathogen interactions.  Specifically, we are interested in how plants protect themselves from pathogen infection using both preformed and induced defense responses.  Using cell biology and genetics, we are investigating how the actin cytoskeleton impacts defense signaling in the model system Arabidopsis thaliana.  We are also using genetics and biochemistry to ask how gene-for-gene resistance signaling is initiated during the early stages of the host-pathogen association.  Finally, a recent project in the lab aims to understand how the downy mildew pathogen Pseudoperonospora cubensis interacts with cucumber.  This work involves a combination of genomics, cell biology and chemistry to dissect the events critical to the onset of resistance in cucumber.  More details about projects, people and future directions can be found throughout this webpage.

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Gene-for-gene ResistanceActin CytoskeletonPseudoperonospora cubensis

Congratulations Dr. Savory!

Congratulations Elizabeth Savory, PhD!

Elizabeth successfully defended her dissertation “Genetic and Transcriptomic Analyses of the Pseudoperonospora cubensis-Cucumis sativus Interaction.

Additionally, her paper, “Alternative Splicing of a Multi-Drug Transporter from Pseudoperonospora cubensis Generates an RXLR Effector Protein That Elicits a Rapid Cell Death” is now available at PLoS One. Congrats Elizabeth!

Day Lab featured in The State News

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Check out The State News for a recent article about research at Michigan State University – United they stand – University Research Corridor aims to bolster Michigan economy with research.  Our very own Leo Yan was on the front page! Image credit: Aaron Snyder/The State News

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